Webinars

Vial fogging is a phenomenon commonly observed in lyophilized biologic drug products and has been widely reported in the pharmaceutical industry. The appearance of vial fogging presents as a haze of dried powder which is visible above where the dried cake meets the inner surface of the vials.

The presentation will discuss the advantages and disadvantages of foam drying, such as improved storage stability of pharmaceutical products at increased temperatures, faster drying cycles, and better preservation of biologic activity.

In the freeze drying world, most of the work and literature published is related to vial freeze drying and does not touch on some of the differences that are only seen when working with bulk materials. This webinar will highlight some of the most common challenges users face when freeze drying bulk material as well as some of the features that users should be attentive to when selecting a freeze dryer to be used in a bulk application.

The emergence of cell and gene therapies and new COVID-19 vaccines brings the promise of treating some of the most challenging diseases. Storage, transport, and delivery of these breakthrough therapies for safe clinical use has its own set of challenges.

Antibody drug conjugates (ADCs) are antibodies equipped with a small number of chemotherapeutic molecules with the aid of a linker system.  They have grown in importance because the antibody targets specific cells where they drop off their payload of chemotherapeutic molecules.  This is a huge advantage to chemotherapy. 

This webinar will demonstrate how the MicroFD with LyoPAT can be used to both develop an optimized lyophilization protocol and then transfer the protocol to a pilot or production scale system.

Due to the product pre-conditioning in individual vials, freeze-drying process can be difficult to design and often results in batches presenting a significant heterogeneity in the quality of the final product. This webinar focuses on the understanding and quantification of the sources responsible for heat and mass transfer variability during the process.

The purpose of this webinar is to describe the types of in-process data that can be collected and provide examples of their use. In-process data collected at full-scale are valuable for demonstrating the success of scale-up, for routine process monitoring, and for solving problems that may occur during the process.

MicroFD^® is a small-scale freeze-dryer where very few vials are loaded: it allows tremendous API savings, beside shortening the stages of batch preparation & loading, condenser defrosting, etc.