About Our Speaker

Serguei Tchessalov is a Research Fellow at Pfizer Inc. He has been actively involved in the evaluation of alternative drying technologies to vial lyophilization.

With a background in pharmaceutical sciences and extensive experience in the development of drying processes, Dr. Tchessalov has contributed significantly to the understanding of spray freeze-drying, spin freeze-drying, and foam drying. His work has focused on the maturity state of these technologies, including their application at laboratory and commercial scales, process understanding, and infrastructure readiness. Dr. Tchessalov’s research has provided valuable insights into the potential benefits and challenges of alternative drying technologies, making him a key expert in the field.

Abstract

The webinar “Evaluation of Alternative Drying Technologies to Vial Lyophilization” will cover the maturity state of various drying technologies, including foam drying, spray freeze-drying, and spin freeze-drying. The presentation will discuss the advantages and disadvantages of foam drying, such as improved storage stability of pharmaceutical products at increased temperatures, faster drying cycles, and better preservation of biologic activity. It will also compare conventional vial freeze-drying with spray freeze-drying in terms of freezing time, drying time, reconstitution time, accuracy of fill, aseptic nature, flexibility in dose, and potential benefits. The webinar will provide insights into the development of reliable models for spray-freezing and rotary drying, as well as the potential applications and pros and cons of spin freeze-drying. Additionally, it will present the results of studies on lipid nanoparticles, adeno-associated virus, and protein, highlighting the impact of different drying technologies on product attributes. The presentation will also address the maturity state of single and multi-vial lab scale units and pilot scale in development for spin freeze-drying. Overall, the webinar will offer a comprehensive overview of the advancements and challenges in alternative drying technologies, providing valuable insights for professionals in the pharmaceutical industry.

Highlights

• Cutting-Edge Drying Technologies: Explore the latest advancements in alternative drying technologies, including spray freeze-drying, spin freeze-drying, and foam drying. Understand the potential benefits of these technologies, such as significantly reduced freezing and drying times, improved product stability, and enhanced process flexibility.
• In-Depth Case Studies: Gain insights from real-world case studies on the application of spin freeze-drying to various formulations, including lipid nanoparticles, adeno-associated virus (AAV), and proteins. Understand the impact of fast freezing on product attributes and the need for further optimization, providing valuable lessons for pharmaceutical development.
• Scale-Up Readiness: Learn about the maturity state of these technologies, from single-vial lab scale units to pilot scale development. Discover the potential for commercial-scale production, with the ability to process 250 vials per day and the availability of GMP grade equipment, offering a glimpse into the future of pharmaceutical manufacturing.