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REVO® Research and Development Freeze Dryer

REVO® Freeze Dryer

Development & Small Scale Production

The REVO Research & Development Freeze Dryer has the largest shelves and best shelf-to-shelf spacing of any freeze dryer in its class offering up to 12 sq ft (1.115 sq M) of shelf area and a condensing rate of 20 Liters in 24 hours. This allows for more product throughput in the same floor space. Using the best components and design techniques combined with the most advanced PC/PLC control system, the REVO R&D Lyophilizer offers data collection and self-testing features. Overall, the REVO R&D Freeze Dryer is the perfect solution for both your protocol development and small scale lyophilization production needs.

Our easy-to-use software provides automatic freeze drying, defrost, system and leak rate testing. Data can be printed either numerically or graphically. This same control system is used on industrial dryers, allowing scaling to production. An interactive maintenance screen simplifies component servicing. All systems are remotely accessible, with customer approval, for trouble-shooting process issues. Now available with Clean in Place.

SYSTEM PERFORMANCE
  • 5 shelf pull down from +20 to –40C in less than 30 minutes
  • Vacuum pull down to 100 mT in less than 20 minutes
  • Vacuum leak rate less than 30 mT per hour
  • Vacuum level 10 mT in clean dry system (-85)
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About the REVO Freeze Dryer

CONTROL SYSTEM

  • PC/PLC with ethernet and remote Internet connectivity
  • Manual and automatic operating modes
  • Graphic and numeric data collection
  • Automatic System and Leak Rate Testing
  • Options for Protocol Optimization and Controlled Nucleation

SHELF SYSTEM

  • Up to 12 sq. ft. of shelf area
  • 12″ x 24″ shelf size
  • Bulk or hydraulic stoppering option, 12 PSI stoppering pressure for 2ml vials
  • 316L stainless steel on all wetted parts

CONDENSER

  • Choke free design
  • External condenser with 6" vapor port
  • Exposed coil condensing surface to eliminate vapor bypass
  • Hot gas defrost

REFRIGERATION

  • Oversized and highly reliable scroll compressors
  • CFC-free, non-proprietary refrigerants

VACUUM

  • Pirani vacuum sensor with solenoid control
  • Gas backfill
  • Corrosion resistant vacuum pump
  • Option: Capacitance manometer with proportional control

FITTINGS

  • Sanitary and KF fittings on all chamber access ports

Note: Specifications subject to change without notice. All specifications based on 20C ambient on 60Hz.

REVO STANDARD FEATURES

SHELF AREA 2 sq. ft. to 12 sq ft (0.186 to 1.115 sqM)
SHELF ASSEMBLY Bulk or Hydraulic Stoppering
SHELF TEMPERATURE RANGE -45ºC to + 65°C (-53C Condenser)
-70ºC to + 65°C (-85C Condenser)
SHELF HEAT TRANSFER Hollow Fluid Filled
SHELF SIZE/FINISH 12″x24″, 316L SS, 20Ra or better (305mm x 610mm)
CONDENSER TEMP -53°C or -85°C
CONDENSER CAPACITY 30L
CONDENSING RATE 20L in 24 hours
CONDENSER STYLE Exposed Coil, 6" Vapor Port
DEFROST Hot Gas
COMPRESSORS (SCROLL) (-53C) 3.5 HP
(-85C) 3.5 HP 1st stage & 2 HP 2nd stage
PRODUCT SENSORS 4, Type T Thermocouples
VACUUM PUMP Corrosion Resistant
VACUUM CONTROL Pirani w/ Solenoid & Needle Valve
Option: Capacitance manometer with proportional control
GAS BACKFILL Included
CONTROL SYSTEM PC/PLC with Opti-Dry Software
TRAYS One per shelf included
CABINET 35″w x 46″d x 75″h
ELECTRICAL FOR -53C UNITS 230V/60Hz, 1ph, 30A
220V/50Hz, 1ph, 30A
380V/50Hz, 3ph, 30A
ELECTRICAL FOR -85C UNITS 230V/60Hz, 1ph, 40A
220V/50Hz, 1ph, 40A
380V/50Hz, 3ph, 25A
VIAL
(ml)
DIA
(mm)
HT
(mm)
# Shelves
      1 2 3 4 5
2 16 41 774 1548 2322 3096 3870
5 22 48 403 806 1209 1612 2015
10 24 58 322 644 966 1288          -
20 29 71 218 436 654          -          -
50 43 81 96 192          -          -          -
100 52 92 65 130          -          -          -

* Capacity data shown in the above chart is an approximation.

Shelves Spacing
(in/mm)
Area
(sq ft/sq m)
1 14.5 / 368 2 / 0.186
2 7.0 / 177 4 / 0.373
3 4.5 / 114 6 / 0.599
4 3.25 / 82 8 / 0.746
5 2.5 / 63 10 / 0.929
6 2.0 / 50 12 / 1.115
DEPTH 1 2 3 4 5 6
10mm 1.8 3.6 5.4 7.2 9.0 10.8
15mm 2.7 5.4 8.1 10.8 13.5 16.2
20mm 3.6 7.2 10.8 14.4 18.0 21.6

* Capacity data shown in the above chart is an approximation.

The REVO R&D Lyophilizer comes complete with PLC controls and a PC for programming and data collection. Our easy-to-use software provides automatic freeze-drying, defrost, and system test. Data can be printed either numerically or graphically. This same control system can be used on industrial dryers, allowing scaling to production. An interactive maintenance screen simplifies component servicing.

OPTI-DRY uses an Ethernet platform for hardware connectivity making data transmission extremely fast. It also provides web connectivity for those who want remote access to their systems.

For R&D, Protocol Development, Small Scale Freeze Drying Production, Cycle Automation, Opti-Dry offers all the tools you need.

 

MECHANICAL

  • Clean room configuration
  • Water Cooled Condenser
  • Butterfly isolation valve on condenser
  • Shelf latching kit to change shelf inter-distance
  • Isolator interface for connection to an isolator
  • Stainless steel door when using solvents
  • LN2 trap to protect your vacuum pump from solvents
  • Clean In Place to wash between different products
  • H2O2 integration for sterilization
  • Controlled Nucleation - FreezeBooster

INSTRUMENTATION AND CONTROLS

  • Auto-Dry Protocol Development
  • Up to 16 thermocouples
  • Resistivity probe
  • 21 CFR Part 11 capable software

VACUUM

  • Capacitance manometer to control the same as production systems
  • Proportional vacuum control (+/-2mT control)
  • Dry vacuum pump for use when processing solvents

SERVICES

  • Startup and training
  • Software Validation
  • Electro-Mechanical Validation documentation
  • IQOQ, FAT and SAT documentation and execution
Click here to learn more about our Clean-In-Place technology featured in the Magnum Freeze Dryer.

 

Click here to watch our Clean In Place (CIP) technology in action.

Require more control of your data? Check out our Revo Pro with LyoPat technology

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Millrock Technology:

Your Freeze Drying Partner

When you purchase a Millrock product, you get more than a freeze dryer. You get a long-term partner delivering industry-changing innovations, high-performing products, and on-call expert support.