Revo® Research and Development Freeze Dryer
Development & Small Scale Production
The REVO Research & Development Freeze Dryer has the largest shelves and best shelf-to-shelf spacing of any freeze dryer in its class offering up to 12 sq ft (1.115 sq M) of shelf area and a condensing rate of 20 Liters in 24 hours. This allows for more product throughput in the same floor space. Using the best components and design techniques combined with the most advanced PC/PLC control system, the REVO R&D Lyophilizer offers data collection and self-testing features. Overall, the REVO R&D Freeze Dryer is the perfect solution for both your protocol development and small scale lyophilization production needs.
Our easy-to-use software provides automatic freeze drying, defrost, system and leak rate testing. Data can be printed either numerically or graphically. This same control system is used on industrial dryers, allowing scaling to production. An interactive maintenance screen simplifies component servicing. All systems are remotely accessible, with customer approval, for trouble-shooting process issues. Now available with Clean in Place. Cooling Methods include water or air Cooled Mechanical Refrigeration or NitroLyo/LN2 Option.
SYSTEM PERFORMANCE
- 5 shelf pull down from +20 to –40C in less than 30 minutes
- Vacuum pull down to 100 mT in less than 20 minutes
- Vacuum leak rate less than 30 mT per hour
- Vacuum level 10 mT in clean dry system (-85)
About the Revo Freeze Dryer
Specifications
CONTROL SYSTEM
- PC/PLC with ethernet and remote Internet connectivity
- Manual and automatic operating modes
- Graphic and numeric data collection
- Automatic System and Leak Rate Testing
- Options for Protocol Optimization and Controlled Nucleation
SHELF SYSTEM
- 2 to 12 sq ft (0.186 to 1.115 sqM)
- 12″ x 24″ shelf size
- Bulk or hydraulic stoppering option, 12 PSI stoppering pressure for 2ml vials
- 316L stainless steel on all wetted parts
CONDENSER
- Choke free design
- External condenser with 6″ vapor port
- Exposed coil condensing surface to eliminate vapor bypass
- Hot gas defrost
REFRIGERATION
- Oversized and highly reliable scroll compressors
- CFC-free, non-proprietary refrigerants
- Water or Air Cooled Mechanical Refrigeration or NitroLyo/LN2 Option
VACUUM
- Pirani vacuum sensor with solenoid control
- Gas backfill
- Corrosion resistant vacuum pump
- Option: Capacitance manometer with proportional control
FITTINGS
- Sanitary and KF fittings on all chamber access ports
Note: Specifications subject to change without notice. All specifications based on 20C ambient on 60Hz.
REVO STANDARD FEATURES |
|
|---|---|
| SHELF AREA | 2 sq. ft. to 12 sq ft (0.186 to 1.115 sqM) |
| SHELF ASSEMBLY | Bulk or Hydraulic Stoppering |
| SHELF TEMPERATURE RANGE | -45ºC to +65°C (-53C Condenser) -70ºC to +65°C (-85C Condenser) |
| SHELF HEAT TRANSFER | Hollow Fluid Filled |
| SHELF SIZE/FINISH | 12″x24″, 316L SS, 20Ra or better (305mm x 610mm) |
| CONDENSER TEMP | -53°C or -85°C |
| CONDENSER CAPACITY | 30L |
| CONDENSER RATE | 20L in 24 hours |
| CONDENSER STYLE | Exposed Coil, 6" Vapor Port |
| DEFROST | Hot Gas |
| COMPRESSORS (SCROLL) | (-53C) 2 HP (-85C) 2 HP 1st Stage and 2 HP 2nd Stage |
| PRODUCT SENSORS | 4, Type T Thermocouples |
| VACUUM PUMP | Corrosion Resistant |
| VACUUM CONTROL | Pirani w/ Solenoid & Needle Valve Option: Capacitance manometer with proportional control |
| GAS BACKFILL | Included |
| CONTROL SYSTEM | PC/PLC with Opti-Dry Gen2 Software |
| TRAYS | One per shelf included |
| CABINET | 35″w x 46″d x 75″h |
| ELECTRICAL FOR -53C UNITS | 230V/60Hz, 1ph, 30A 220V/50Hz, 1ph, 30A 380V/50Hz, 3ph, 30A |
| ELECTRICAL FOR -85C UNITS | 230V/60Hz, 1ph, 40A 220V/50Hz, 1ph, 40A 380V/50Hz, 3ph, 25A |
Vial Capacity
| VIAL (ml) |
DIA (mm) |
HT (mm) |
# Shelves | ||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |||
| 2 | 16 | 41 | 480 | 960 | 1440 | 1920 | 2400 |
| 5 | 22 | 48 | 241 | 482 | 723 | 964 | 1205 |
| 10 | 24 | 58 | 199 | 398 | 597 | 796 | - |
| 20 | 29 | 71 | 136 | 272 | 408 | 544 | - |
| 50 | 43 | 81 | 55 | 110 | 165 | - | - |
* Capacity data shown in the above chart is an approximation.
Shelf Configuration
| SHELVES | SPACING (in/mm) |
Area (sq ft/sq M) |
|---|---|---|
| 1 | 14.5 / 368 | 2 / 0.186 |
| 2 | 7.0 / 177 | 4 / 0.373 |
| 3 | 4.5 / 114 | 6 / 0.599 |
| 4 | 3.25 / 82 | 8 / 0.746 |
| 5 | 2.5 / 63 | 10 / 0.929 |
| 6 | 2.0 / 50 | 12 / 1.115 |
Bulk Fill
| Depth | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|
| 10mm | 1.0 | 2.3 | 3.5 | 4.6 | 5.8 |
| 15mm | 1.7 | 3.5 | 5.2 | 6.9 | 8.7 |
| 20mm | 2.3 | 4.7 | 7.0 | 9.2 | 11.6 |
* Capacity data shown in the above chart is an approximation.
Opti-Dry Gen2 PC/PLC Control
Our new Opti-Dry Gen2 software provides sophisticated and intelligent tools to easily develop and execute both simple and advanced freeze-drying cycles.
Millrock Reporter is included with every system, providing full batch reporting, including recipe, graphs, data, and alarms in a single report.
Predictive maintenance with advanced system monitoring delivers cost-savings and enables maximum uptime by tracking and monitoring
the condition and performance of equipment during normal operation.
This same control system is used on industrial freeze dryers, allowing scaling to production. All systems are remotely accessible, with customer approval, for troubleshooting process issues.
Available Options
MECHANICAL
- Clean room configuration
- Water Cooled Condenser
- Butterfly isolation valve on condenser
- Shelf latching kit to change shelf inter-distance
- Isolator interface for connection to an isolator
- Stainless steel door when using solvents
- LN2 trap to protect your vacuum pump from solvents
- Clean In Place to wash between different products
- H2O2 integration for sterilization
- Controlled Nucleation – FreezeBooster
INSTRUMENTATION AND CONTROLS
- Auto-Dry Protocol Development
- Up to 16 thermocouples
- Resistivity probe
- 21 CFR Part 11 capable software
VACUUM
- Capacitance manometer to control the same as production systems
- Proportional vacuum control (+/-2mT control)
- Dry vacuum pump for use when processing solvents
SERVICES
- Startup and training
- Software Validation
- Electro-Mechanical Validation documentation
- IQOQ, FAT and SAT documentation and execution
REFRIGERATION
- Water or Air Cooled Mechanical Refrigeration
- Natural Refrigerants Including LN2 Option
Applications
Clean-In-Place in Freeze Drying: How It Works
Click here to learn more about our Clean-In-Place technology featured in the Magnum Freeze Dryer.
Click here to watch our Clean In Place (CIP) technology in action.
*Standard CIP systems are designed for water use only. Other medias may not be compatible and need to be disclosed and/or approved prior to contract.
Let’s Talk About Your Capacity Strategy
Whether you’re optimizing development, planning commercial production, or scaling through multiple systems, we can help you determine the right approach.