Leaders in Freeze Drying Innovation
Freeze Dryers / Lyophilizers from Laboratory to Production

MicroFD R&D Freeze Dryer

MICROFD WITH LYOSIM & LYOPAT

Analyze -> Optimize -> Transfer

SPECIAL FEATURES

  • Uses less valuable of your valuable product for R&D
  • R&D and cycle transfer with as few as 7 vials
  • Determines Kv, Rp and other critical process parameters/li>

 

CONTROL SYSTEM

  • PC/PLC with ethernet and remote Internet connectivity
  • Manual and automatic operating modes
  • Graphic and numeric data collection

 

SHELF SYSTEM

  • 6” Diameter Shelf
  • -60 to +60C
  • Fluid filled Stoppering/radiant plate
  • Electric stoppering
  • 316L on all wetted parts

 

CONDENSER

  • External with Isolation valve
  • Exposed coil condenser for maximum efficiency
  • Hot gas defrost
  • 1L total capacity
  • -70C

 

REFRIGERATION

  • Cascade refrigeration system
  • CFC-Free, non-proprietary refrigerants

 

VACUUM

  • Pirani vacuum sensor standard
  • Capacitance Manometer sensor standard
  • Advanced Proportional Vacuum control standard
  • Gas backfill standard
  • 65LPM corrosion resistant vacuum pump with easy access

 

OTHER

  • Temperature controlled walls in product chamber
  • Built-in Controlled Nucleation (FreezeBooster)
  • Sanitary style fittings on all sensor and vacuum ports
  • Built-in validation port – sanitary fitting

Analyze -> Optimize -> Transfer

The MicroFD with LyoSim and LyoPAT does more than larger lab freeze dryers do but with fewer vials. Provides all critical process parameters AND provides heat flux measurement utilizing AccuFlux. Fewer vials (ie 19 vials if using a 10cc serum vial) means significant time savings in set-up and downtime.

LYOPAT

The Millrock MicroFD with LyoSim comes standard equipped with LyoPAT.

LyoPAT is a dynamic, closed loop process control of Freezing,
Primary Drying and Secondary Drying.

LyoPAT is a combination of methods including controlled nucleation and heat flow control that produces an ice crystal structure that is more favorable to sublimation and controls the product temperature during primary drying.

MicroFD with scientist, freeze drying scientist, small R&D freeze dryer, small R&D Lyophilizer, Micro freeze dryer

LyoPAT controls allow you, the end user, to select the various methods available for both freezing & primary drying.

  • Product Temperature – Control by either Thermocouple or AccuFlux (Heat Flow)
  • Nucleation – Controlled Nucleation or no induced nucleation
  • Freezing – Controlled by a recipe or AccuFlux (Heat flow)
  • Drying – Controlled by a recipe or AccuFlux (Heat flow)

A New Intuitive Controller

microFD Analyze mode
Utilize Analyze Mode and operate the MicroFD with your existing freeze drying cycle.  The MicroFD will execute your run and report on all critical process parameters.
MicroFD with LyoSim & Lyopat
Utilize Optimize mode and the MicroFD will utilize a control feedback loop to optimize the the freeze drying run.  You can choose which control feedback mechanisms you wish to engage in the program.

WHAT DOES LYOPAT DO?

Take the guess work out of your freeze drying process!

 

LyoPAT enables you to continuously monitor your entire
freeze drying process:

 

Freezing

 

  • Nucleation
  • % of Ice Formed During Nucleation
  • Crystal growth rate
  • 80-95% of the freezing process
  • End of Freezing

 

Primary Drying

 

  • Kv
  • Mass Flow
  • Rp
  • Product Temperature (without a thermocouple)
  • End of Primary Drying

 

LyoPAT is the only Process Analytical Technology that can determine the critical process parameters in any freeze dryer for your specific application. Protocol transfer is simplified!

 

If process improvement is your goal….LyoPAT enables you to monitor and control the freezing and drying processes to determine the effect of different protocols on product temperature and primary drying times.

 

  • Compare your current freezing and
    drying protocols to new ones.
  • Test the effect of controlling crystal
    growth during freezing.
  • Test the effect of controlled nucleation.
  • Test the effect of changing shelf temperatures and vacuum levels during primary drying on your product temperature and mass flow rate.

A Series of Experiments Showing the Progression of Cycle Development in a MicroFD.

4 runs with improvements

Step 1:   Previously utilized freeze drying cycle that analyzes the heat flux and other critical parameters.

Step 2:  The addition of Controlled Nucleation creating a more homogenous product crystalline structure that also allows heat flow events to be amplified because they happen within the same time frame of one another.

Step 3:  Illustrates the addition of post nucleation AccuFlux heat flow control.  This helps control crystal size and thus has an effect on cake resistance to vapor flow.

Step 4:  All MicroFD with LyoSim and LyoPAT tools are used to optimize the freeze drying cycle resulting in a time reduction of 60% from the Step 1 cycle.

New Millrock Batch Reporter

freeze dry batch reporting

Millrock Batch Reporter allows you to configure your data output in the format that you like best and provides all of the critical process parameters.

* Patented and Patent Pending technology.
Note: Specifications subject to change without notice. All specifications based on 20C ambient on 60Hz.