Ling Zhu is a graduate student in Dr.Robin Bogner’s lab in the Department of Pharmaceutical Sciences at the University of Connecticut, where he engages in the design and optimization of freeze drying protocols for pharmaceutical formulations.

Ling shares his research results on the influence of freezing parameters on the drying process and final product structures.

Abstract
This webinar will highlight the influence of controllable factors such as ice nucleation temperature and post nucleation shelf-cooling rate on the primary drying rate, dry product resistance and porous structure characterized by pore size distribution, specific surface area and X-ray microCT imaging. As the product resistance is lowered by slower freezing, this case study will show that the primary drying time can be reduced to 1/3. We will discuss the relationship between the features of the lyophilized porous structure and the resistance to mass transfer in primary drying.

Webinar Highlights

• Influence of freezing patterns
• Porous structure characterization after freeze drying
• Resistance to mass transfer during primary drying