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LyoPAT® – New Technology for FD Research and Development

The Ultimate Tool for Cycle Optimization & Transfer


LyoPAT® is the combination of our proprietary AccuFlux® & AutoDry, with optional FreezeBooster® technology.





Batch Size Independent

Cycle Optimization

Post Nucleation Freezing Control

Measure Kv

Enhances Quality

Enables Modeling of Production Systems in the Lab

Assists in Cycle Transfer

LyoPAT® combines innovative and powerful control technology into a single integrated control platform that provides research & development and cycle transfer scientists the best tools available on the market today.  Included are:

AccuFlux® Heat Flux Measurement

  • Direct measurement of shelf surface temperature and Kv during the cycle
  • Determine the values for critical process parameters to enable transfer between freeze dryers
  • Evaluate the effect of different freezing methods, including Controlled Nucleation, on primary drying
  • Evaluate the best post-nucleation heat flow to produce the best crystal structure for your application
  • Evaluate the effect of different shelf temperatures and vacuum levels on product temperature and mass flow during primary drying
  • Evaluate critical process parameters for different freeze dryers
  • Evaluate critical process parameters for application changes, such as vial or product fill
  • Develop optimized freezing and primary drying cycles

AutoDry Cycle Optimization (patent 8434240)

  • Feedback directly from product to controller
  • Maximize heat input while maintaining product below critical melting temperature during primary drying
  • Minimize primary drying cycle

Optional FreezeBooster®

  • Control nucleation of the free ice
  • Create a more homogenous ice matrix across the vials in a single batch
  • Control batch to batch freezing uniformity
  • Study freezing approaches and its effect on the product and the product cycle

LyoSim™ on the MicroFD®

  • Simulate/Emulate the conditions of your larger freeze dryer using as few as 19 vials
  • Eliminate edge effect with LyoSim to study center vial conditions
  • Cycle transfer by design vs simply run time extension

What Does LyoPAT® Do?

Millrock Technology® has pioneered the use of heat flux sensors to measure and control the heat transfer dynamics of the freeze drying process. This unique technology provides measurement of the Critical Process Parameters in all stages of the freeze drying process, including freezing, primary drying and secondary drying. LyoPAT® enables the user to analyze, improve and optimize their freeze drying processes in the lab and easily transfer the protocols to production.

LyoPAT® provides direct measurement of vial thermal conductivity (Kv) and heat transfer parameters (heat flux, mass flow, product temperature, cake resistance, etc.).

LyoPAT® control software enables existing protocols to be run for analysis or fully optimized by selecting a combination of control parameters.

Take the guess work out of your freeze drying process!

LyoPAT® enables you to continuously monitor your entire freeze drying process:

process analytical technologyLyoPAT® enables you to continuously monitor your entire freeze drying process:


  • Heat Removed during the freezing process
  • % Frozen by Nucleation
  • Heat Flow during ice crystallization
  • End of Super Cooling (ready for nucleation)
  • Controlled Nucleation
  • Heat flow control post-nucleation for crystal growth control
  • End of Freezing advancement to primary drying based on heat flow stability

Primary Drying

process analytical technology

  • dQ/dt – Heat Flow
  • Kv – Vial Conductivity
  • Tp – Product Temperature
  • dM/dt – Mass Flow
  • % Dry
  • End of Primary Drying
  • End of Secondary Drying
  • Control the process from the product temperature, not the shelf temperature
  • And more….

LyoPAT® is the only Process Analytical Technology that can determine the critical process parameters in any freeze dryer for your specific application. Protocol transfer is simplified!

If freeze drying process improvement is your goal…

LyoPAT ® enables you to monitor and control the freezing and drying processes to determine the effect of different protocols on product temperature and primary drying times. This means you can:

    • Compare your current freezing and drying protocols to new ones.
    • Test the effect of controlling crystal growth during freezing.
    • Test the effect of controlled nucleation.
    • Test the effect of changing shelf temperatures and vacuum levels during primary drying on your product temperature and mass flow rate.

LyoPAT ® gives the user access to information that did not exist before. This information enhances the development capabilities of your freeze dryer and provides alternatives for scalability as well as quality control.

process analytical technologyMillrock’s Accuflux® technology, in conjunction with Millrock’s FreezeBooster® Controlled Nucleation Technology, offers a multivariate data acquisition and data analysis platform. Combined, these technologies are called