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MICROFD Small Research Freeze Dryer

SYSTEM SPECIFICATIONS
  • Shelf temperature range (-70C to +65C)
  • Condenser Temperature -75C

The MicroFD with LyoSim and LyoPAT does more than larger lab freeze dryers do but with fewer vials.  Provides all critical process parameters AND provides heat flux measurement utilizing AccuFlux.  Fewer vials (ie 19 vials if using a 10cc serum vial) means significant time savings in set-up and downtime. 

LYOPAT

The Millrock MicroFD with LyoSim comes standard equipped with LyoPAT.

LyoPAT is a dynamic, closed loop process control of Freezing,
Primary Drying and Secondary Drying.

LyoPAT is a combination of methods including controlled
nucleation and heat flow control that produces an ice crystal
structure that is more favorable to sublimation and controls
the product temperature during primary drying.

MicroFD Lyopat

LyoPAT controls allow you, the end user, to select the various methods available for both freezing & primary drying.

  • Product Temperature – Control by either Thermocouple or AccuFlux (Heat Flow)
  • Nucleation – Controlled Nucleation or no induced nucleation
  • Freezing – Controlled by a recipe or AccuFlux (Heat flow)
  • Drying – Controlled by a recipe or AccuFlux (Heat flow)
MICROFD WITH LYOSIM AND LYOPAT HIGHLIGHTS
SPECIAL FEATURES
  • Ultimate control with LyoSim ring and AccuFlux
  • Controlled nucleation with FreezeBooster
  • Optimization of Primary Drying with AutoDry
CONTROL SYSTEM
  • PC/PLC with ethernet and remote Internet connectivity
  • Manual and automatic operating modes
  • Graphic and numeric data collection
SHELF SYSTEM
  • 6” Diameter Shelf
  • Fluid filled Stoppering/radiant plate
  • Electric stoppering
  • 316L on all wetted parts
CONDENSER
  • External with Isolation valve
  • Exposed coil condenser for maximum efficiency
  • Hot gas defrost
  • 1L total capacity
REFRIGERATION
  • Cascade refrigeration system
  • CFC-Free, non-proprietary refrigerants
VACUUM
  • Pirani vacuum sensor standard
  • Capacitance Manometer sensor standard
  • Advanced Proportional Vacuum control standard
  • Gas backfill standard
  • 65LPM corrosion resistant vacuum pump with easy access
OTHER
  • Temperature controlled walls in product chamber
  • Built-in Controlled Nucleation (FreezeBooster)
  • Sanitary style fittings on all sensor and vacuum ports
  • Built-in validation port – sanitary fitting

MICROFD™ Series

R&D Freeze Dryer/Lyophilizer

APPLICATIONS
  • R&D
  • Vials

 

 

Download our brochure for The MicroFD Series

WHAT DOES LYOPAT DO?

Take the guess work out of your freeze drying process!

LyoPAT enables you to continuously monitor your entire
freeze drying process:

Freezing

  • Nucleation
  • % of Ice Formed During Nucleation
  • Crystal growth rate
  • 80-95% of the freezing process
  • End of Freezing

Primary Drying

  • Kv
  • Mass Flow
  • Rp
  • Product Temperature (without a thermocouple)
  • End of Primary Drying

LyoPAT is the only Process Analytical Technology that can
determine the critical process parameters in any freeze
dryer for your specific application. Protocol transfer is
simplified!

If process improvement is your goal….LyoPAT enables you
to monitor and control the freezing and drying processes
to determine the effect of different protocols on product
temperature and primary drying times.

  • Compare your current freezing and
    drying protocols to new ones.
  • Test the effect of controlling crystal
    growth during freezing.
  • Test the effect of controlled nucleation.
  • Test the effect of changing
    shelf temperatures and vacuum
    levels during primary drying on
    your product temperature and mass
    flow rate.

MICROFD Series

MICROFD Series

* Patented and Patent Pending technology.
Note: Specifications subject to change without notice. All specifications based on 20C ambient on 60Hz.